Li+ and sickling of homozygous HbS cells.
نویسندگان
چکیده
Vol.31, No. 4, 1985 649 tecting hypercholesterolemia must have the best possible analytical performance. We suggest that, in screening a population for hypercholesterolemia, serum or plasma samples are preferable to blood spots on fiter paper. Instruments such as the Cobas-Bio centrifugal analyzer require less than 50 L of sample and the typical overall CV is 4% for assays of cholesterol in plasma.
منابع مشابه
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In sickle cell trait (SCT), hemoglobin A (HbA) and S (HbS) are co-expressed in each red blood cell (RBC). While homozygous expression of HbS (HbSS) leads to polymerization and sickling of RBCs resulting in sickle cell disease (SCD) characterized by hemolytic anemia, painful vaso-occlusive episodes and shortened life-span, SCT is considered a benign condition usually with minor or no complicatio...
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A homozygous mutation in the gene for (HbA), is the proximate cause of sickle cell disease (SCD). Sickle hemoglobin (HbS) shows peculiar biochemical properties, which lead to polymerizing when deoxygenated. HbS polymerization is associated with a reduc increased red cell density which further accelerate HbS polymerization. Dense, dehydrated erythrocytes are likely to undergo instant polymerizat...
متن کاملHemoglobin S polymerization: primary determinant of the hemolytic and clinical severity of the sickling syndromes.
We examined the extent to which the intracellular polymerization of sickle hemoglobin (HbS) can account for the severity of anemia and of vaso-occlusive manifestations in the various sickling syndromes. Polymer formation in sickle cell disease depends principally on the intraerythrocytic hemoglobin composition and concentration. In our studies, the polymer fraction in sickle red cells was deter...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 31 4 شماره
صفحات -
تاریخ انتشار 1985